Runx3 expression in gastrointestinal tract epithelium: resolving the controversy

Author reply to: RUNX3 is expressed in the epithelium of the gastrointestinal tract

The article by Levanon et al (2011) reports that expression of the transcription factor Runx3 is undetectable in gastrointestinal (GIT) epithelium. These results contradict our results, particularly those in Li et al (2002), which indicate that Runx3 is strongly expressed and functions as tumour suppressor in GIT. Here, I aim to clarify the issues by summarizing the findings associated with thi...

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function

The Runx3 transcription factor regulates cell fate decisions during embryonic development and in adults. It was previously reported that Runx3 is strongly expressed in embryonic and adult gastrointestinal tract (GIT) epithelium (Ep) and that its loss causes gastric cancer. More than 280 publications have based their research on these findings and concluded that Runx3 is indeed a tumour suppress...

Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumor suppressor functio

Resolving the Infinitude Controversy

A simple inductive argument shows natural languages to have infinitly many sentences, but workers in the field have uncovered clear evidence of a diverse group of ‘exceptional’ languages from Proto-Uralic to Dyirbal and most recently, Pirahã, that appear to lack recursive devices entirely. We argue that in an information-theoretic setting non-recursive natural languages appear neither exception...

Resolving the Neogrammarian Controversy

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